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In acute myeloid leukemia, the m6A methyltransferase METTL3 and the reader protein IGF2BP3 maintain high-level serine synthesis by recognizing and stabilizing the mRNAs of SSP-related genes including ATF4, PHGDH and PSAT1, meeting the high metabolic demands of cancer cells, particularly leukemia stem/initiating cells (93)
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Aggressive tumors often overactivate FAK signaling to invade tissue, and they rely on new blood vessels to feed a growing tumor
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