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doi: 10.15252/embr.201948781, 52

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” Being in bucket 3 is NOT an endorsement There’s much more nuance to this It means that the underlying molecule has the strongest scientific footing of the 3 But it doesn’t automatically mean it’s safe Or that the off-label use helps for the indication that you might want to take it for Or even that the risk-benefit calculation works for you, especially if you purchase it on the gray market The practical conclusions differ by bucket In bucket 1, there is not enough scientific foundation to justify use In bucket 2, the biology may be real, but the claimed clinical benefit has NOT been demonstrated Or the potential harm that arises from using it would probably lead someone (like a company that’s developing it) to abandon it The development history on many of the peptides in this bucket should probably temper your enthusiasm In bucket 3, the most reasonable approach is to use the product with the strongest characterization and oversight You should be clear about what, if anything, you’re gaining by using a less characterized version of that peptide And what risks you’re accepting or willing to accept by substituting it for the more well-studied drug (more details later) Figure 2