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Individual treatment groups were: (1) DMSO vehicle control (0.0003%, corresponding to the DMSO concentration in the high BPA group), (2) water control, (3) 0.001 µM (low) BPA, and (4) 0.1 µM (high) BPA
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Results of mechanistic pathway analysis indicated that the detrimental effects of CCH might be associated with decreased gene expression of PPAR-γ co-activator1α (PGC-1α) and its upstream transcription factor Sirt1, while NAD+ treatment markedly reversed their decrease
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