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A long-term stability study (over an 8-month period at 4, −4 and −20°C) of 26 sedative−hypnotics including alprazolam was carried out in six toxicological matrices: ante-mortem blood in potassium oxalate: sodium fluoride (1:10), post-mortem blood in potassium oxalate: sodium fluoride (1:10), post-mortem urine in sodium fluoride, homogenized liver (20 g diluted 1:3 with deionized water), homogenized brain (20 g diluted 1:2 with deionized water), and homogenized gastric contents (1:100 with deionized water)

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