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This effect is achieved through inhibition of tyrosine kinase activity in VEGFR2, VEGFR3, PDGF-β, KIT, and FLT-3 receptors 170
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Secondly, since the ionized HS − form carries an overall negative charge, it requires facilitated diffusion and therefore specific transporters, such as anion exchange protein AE1 present on erythrocytes to enter cells [29]
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