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Proper levels help prevent nerve damage and may reduce symptoms like tingling or numbness, especially in adults and individuals with diabetes

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It might be argued that for the long time scale of PD progression, apoptosis is an acute cellular event that on the surface does not perfectly explain the development of PD, but when patients start to have detectable parkinsonism symptoms, there is usually at least 40–60% dopaminergic neuronal loss in the substantia nigra (Giguère et al., 2018), suggesting progressive accumulation of neuronal loss