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Mechanism of peroxidase activity for hydrogen peroxide reduction by the... | Download Scientific Diagram

Apparently, metformin acts directly on gut bacteria to increase their vitamin B12 uptake, leading to increasing competition for available dietary vitamin B12 and ultimately to human vitamin B12 deficiency (55)

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Spermidine, in contrast, offers broader systemic benefits, particularly in terms of neuroprotection and cognitive health, while also contributing to overall longevity through its modulation of autophagy