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This repression limits cystine uptake, depleting GSH and promoting ferroptotic cell death

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Possible Pathophysiologic Mechanisms While there are no established neural correlates of PIMD, the classic experiments in non-human primates by Byl and colleagues [ 143 ] provide the basis for the notion that single (e.g., amputation) or repetitive (e.g., overuse) peripheral injury results in central neuronal reorganization and altered motor activity, such as tremor or dystonia, in the affected body part [ 144 ]