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Calcium The regulation of intracellular Ca 2+ is a metabolically expensive process that requires the actions of ATP-dependent pumps [118] and, therefore, results in increased mitochondrial activity and concomitant increased ROS generation
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Supplementation of sodium selenite in mice protected kidneys from cadmium-induced oxidative stress and prevented apoptosis through mitochondrial pathways ( c release, and caspase activation, and prevented a decrease in voltage dependent anion channels, all of which inhibit mitochondrial signaling of cell apoptosis
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