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In an early endeavor, Lakhdari and colleagues utilized a nuclear factor-kB (NF-kB) activation screen to identify 171 clones from a 2,640-clone human gut microbiome fosmid library, showing modulation of NF-kB reporter activity (Lakhdari et al., 2010)

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One question is why GsMTx4 affects many key physiological processes in vitro , but has little effect on normal physiological processes in vivo , yet has a strong therapeutic effect on pathology