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To explore this hypothesis, we tested mitragynine ( 1 ), 7-hydroxymitragynine ( 2 ) and speciofoline ( 3 ) for µ-opioid receptor inhibition of forskolin-stimulated cyclic-AMP (cAMP) accumulation and for their ability to recruit β-arrestin-2 in CHO-K1 cells stably expressing the µ-opioid receptor
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