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Moreover, visceral fat is likely to return in anyone who discontinues their tesamorelin therapy, whereas patients who’ve taken semaglutide (e.g., Ozempic) have seen at least some longer-lasting health outcomes after ending their treatment.14 29 Therefore, there are three takeaways about tesamorelin and abdominal fat: Tesamorelin may be able to reduce your morbidity for serious chronic health conditions