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Because these are two different rate-limiting steps, addressing only one leaves the other in place
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7.3.2 Biomarker standardization challenges The practical implementation of ferroptosis biomarkers faces difficulties in standardizing measurements of reactive lipid species like MDA and 4-HNE across clinical laboratories, defining clinically validated cut-off values for therapeutic decision-making, and the invasive nature of obtaining optimal samples like BALF for routine monitoring
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