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Since July 1, 2023, CMS requires either modifier JW or modifier JZ on all single-dose or single-use vial claims

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Pre-clinical research has examined whether the fragment’s activity is mediated through a distinct adipocyte receptor or via cross-talk with established adrenergic pathways — with studies using beta-adrenergic antagonists suggesting that the fragment’s lipolytic activity is at least partly dependent on functional adrenergic signalling in adipose tissue