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Furthermore, incubation of HAEC with 20 µM quercetin for 6 or 18 h caused a significant increase in GCLM protein levels, while GCLC protein levels were only significantly elevated after 18 h of incubation (Fig

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The first step is the combination of amino acids glutamate and cysteine by γ-glutamyl cysteine synthetase, also known as glutamate-cysteine ligase (GCL), to form gamma-glutamate-cysteine (γ-Glu-Cys) (Bottino et al., 2021, Lu, 2013, Wu et al., 2004)