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It tested oral AOD-9604 doses of 1, 5, 10, 20, or 30 mg once per day after a two-week placebo run-in period

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Because unbound drug concentration is determined by dosing rate and clearance—which is not altered, in the case of these low-extraction-ratio drugs, by protein binding—increases in dosing rate will cause corresponding changes in the pharmacodynamically important unbound concentration