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Acknowledgements We are grateful for the excellent technical assistance provided by the Core Facility for Scientific Research-USP (CEFAP-USP) in conducting animal imaging with the IVIS Spectrum system

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Conclusions To summarize, the 68-week treatment with coadministered cagrilintide and semaglutide resulted in substantial and clinically meaningful weight loss in adults with overweight or obesity, significantly outperforming monotherapies and placebo (- 5.5% vs

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