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Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee — Osteoarthritis Cartilage 2006 View source MSM + Glucosamine: The Combo Effect One of the most cited MSM trials is Usha and Naidu (2004), which compared 4 groups in 118 patients with knee OA over 12 weeks: MSM 1,500 mg alone, glucosamine 1,500 mg alone, the combination, and placebo