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For instance, both chronic social defeat stress in mice and learned helplessness in rats are associated with decreases in spine density in the prelimbic medial prefrontal cortex, CA3 of the hippocampus, and the dentate gyrus, along with increases in spine density in the nucleus accumbens (Qu and others 2018

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10.1016/j.neurobiolaging.2015.10.039 Neurobiol Aging 394 TehraniS.DavisL.CepurnaW.ChoeT.LozanoD.MonfaredA.et al (2016)