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Ethacrynic acid is found to bind in a nonproductive mode to one of the ligand binding sites of the enzyme (the H site) while the glutathione binding site (G site) is occupied by solvent molecules

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However, a recent study has proposed the flowering time control protein A (FCA) and the chloroplastic magnesium protoporphyrin-IX chelatase H subunit (CHLH) as candidates for ABA receptors, both of which have been shown to bind ABA [196]