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In trials such as NADIM, 242 NADIM II, 197 LCMC3, 243 NEOSTAR, 244 Sakk 16/14, 245 and CHECKMATE-816, 191 higher levels of PD-L1 are enriched in patients who achieve a pathological complete response (pCR), however, PD-L1 levels showed no correlation with PFS or OS (seen in NADIM and Sakk 16/14)