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16,321,322 Both neurons and Schwann cells express insulin receptors (IRs), particularly in sensory neurons of DRG and at nodes of Ranvier

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Although methylcobalamin and adenosylcobalamin are the two coenzyme forms required for the body’s chemical reactions, their supplementation isn’t more efficient than cyanocobalamin or hydroxocobalamin because all B12 forms must first be stripped of their side groups before conversion to the coenzyme forms (Obeid, 2015)