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Anticholinergics (Biperiden, Trihexyphenidyl, Ben-zotropine) Anticholinergics are traditionally used to reverse the EPS resulting from acetylcholine/dopamine imbalance at the nigrostriatal level [75]

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Over the 16-week treatment period, the decline in ALS Functional Rating Scale–Revised (ALSFRS-R) scores was smaller in the MeCbl group than in the placebo group, and adverse event rates were similar between groups.6 6.2 Peripheral Neuropathy and Axonal Degeneration A phase I/II open-label trial evaluated 14 patients with chronic immune-mediated or hereditary neuropathies and electrodiagnostic evidence of axonal degeneration