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BVR-A is a direct target of the IR kinase activity, and as part of a regulatory loop BVR-A phosphorylates IRS1 on inhibitory Ser residues to prevent IRS1 aberrant activation in response to IR

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Risk-of-bias reduction strategies such as robust randomization methods, allocation concealment, blinding of outcome assessors, and intention-to-treat analysis should be incorporated to improve internal validity and reproducibility