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ARA 290 has been evaluated extensively in a wide spectrum of preclinical models, including diet-induced insulin resistance (10), diabetic retinopathy (11), diabetic autonomic neuropathy (12), myocardial infarction (13), chronic heart failure (14), burns (15), traumatic brain injury (16,17) and shock-induced multi-organ failure (18), among others

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[207] observed significantly higher mRNA levels of HIF1A in the placenta of monochorionic twins with intrauterine growth restriction, particularly in fetuses with restricted growth