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It consists of a polysaccharide fraction derived from Aloe vera , Malva sylvestris , and Althea officinalis , along with a flavonoid fraction from Glycyrrhiza glabra and Matricaria recutita

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INO derived from gut microbiota further supports T-cell differentiation and improves responses to immune checkpoint inhibitors (92, 93), highlighting its dual immunoregulatory role ( Figure 1 )