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Because it competes at the nicotinamide substrate site rather than the SAM cofactor site, it is also used as the substrate-competitive reference compound against which bisubstrate and covalent NNMT inhibitors are benchmarked

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▼ Pre-filling syringes reduces effective dose by 5–8% over 24 hours due to peptide adhesion to syringe walls, which compounds across multi-day protocols and undermines dosing consistency