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12 , 18 , 20 , 22 – 24 The comparators of interest varied across the included studies and guidelines and were described as: - Placebo 12 , 18 , 22 – 24 - 100 to 200 mg of doxycycline, twice daily for 20 days 23 - 10 day course of amoxicillin 18 - Tick removal within 24 to 36 hours 12 , 24 - Lifestyle and daily methods to prevent a tick bite: Avoiding areas with ticks, 24 daily body checks for ticks, 12 , 22 , 24 bathing or showering within two hours of tick exposure, 22 , 24 tick repellents, 22 , 24 protective clothing, 22 , 24 placing clothes in a dryer for up to an hour, 22 landscape modifications 22 , 24 - Watchful waiting 23 - Patient education (prevention of future bites, as well as potential manifestations of Lyme disease and other tick-borne diseases)