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It has also been indicated that apelin, a bioactive peptide, provides protection against AKI by reducing inflammation, inhibiting apoptosis, preventing lipid oxidation, suppressing MFF expression, and preserving the expression of SIRT3 and OPA1 [ 41 ]

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The most-developed and most-distinctive research application for 5-Amino-1MQ is in adipose tissue biology , anchored on a landmark 2014 Nature paper by Kraus and colleagues that established NNMT as a central regulator of adipose energy metabolism