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Pungent vanilloids such as capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a major pungent of hot chili pepper ( Capsicum annuum ) [206, 223], and (10)-shogaol from ginger ( Zingiber officinale ) also activate phase II detoxification enzyme expression in a Nrf2-dependent manner [207]

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Also, patients should be warned about the danger of taking folic acid in place of vitamin B 12 , because the former may prevent anemia but allow progression of subacute combined degeneration

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