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The acronym, NAT, is the more broad-spectrum arylamine N-acetyltransferase that also acetylates serotonin, which allows for the production of melatonin in species that are deficient in AANAT and incorrectly defined as melatonin knock out ( Figure 1 Quay was the first to document that pineal melatonin synthesis was cyclic and that its production was clearly higher at night than during the day ( Figure 1 )