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This indicates that the transition from single-celled heterotrophic protozoa to multicellular heterotrophic metazoans was associated with duplication and specialization of the Gsr gene to generate a new TrxR gene [53, 54], and in most cases, loss of the ancestral TrxR gene

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High VEGF-A level at baseline was consistently associated with worst outcomes in patients treated either with TKI or with ICI