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The colon has the largest microbial load in the body and contains about 10 14 bacteria with the dominant phyles of Firmicutes (renamed Bacillota), Bacteroidetes (Bacteroidota), Actinobacteria (Actinomycetota), and Proteobacteria (Pseudomonadota) ( Enterococcus , Lactobacillus , Ruminicoccus , Bacillus , and Clostridium , representing 95% of the Firmicutes phylum
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DPT3f enhances FSP1/CoQ 10 pathway antioxidant activity by upregulating FSP1 protein expression, promotes CoQ 10 conversion to reduced CoQ 10 H 2 to scavenge lipid peroxides, thus inhibiting dopaminergic neuron ferroptosis, protecting SN neurons and alleviating PD-related damage (230)
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