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as a result, subcutaneous injections and intranasal delivery are the predominant methods used in research, though both routes present practical challenges for routine clinical use

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We found that, whereas the number of MBP+ axons was not affected by SNT at the proximal side, a significant reduction in myelinated nerve fibers occurred at the distal end of the lesioned nerve in comparison to the intact contralateral limb and to the proximal end of the same transected nerve (Figure 8f)