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The International Ketogenic Diet Study Group (IKDSG) recommends thorough laboratory diagnosis before and during KD to ensure optimal safety and effectiveness (62, 66)
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Notably, their uncontrolled activation (i.e., under inflammatory/neurotoxic exposure and upon brain injury) favor a switch toward the so-called AS-1 and M-1 harmful glial phenotype, which may directly affect neurons by releasing various molecular mediators, such as pro-inflammatory cytokines, reactive oxygen species (ROS), and reactive nitrogen species (RNS), which in turn perpetuate/exacerbate glial activation, resulting in increased mDA neuron vulnerability and cell death (Figure 3)