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Whether Epithalon can consistently achieve this effect in humans remains an active area of investigation, but the possibility of supporting the body’s natural melatonin production remains one of the most biologically plausible explanations for its reported effects on sleep

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Its discovery added a genuinely new category of signalling molecule to the field — mitochondrial-derived peptides, of which MOTS-c and humanin are the best characterised examples — and its mechanistic overlap with exercise and metformin has made it a natural candidate for research into metabolic disease and healthy ageing specifically

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