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Over time, some of the key vitamin B6 deficiency symptoms in adults can include: Changes in mood, such as irritability, anxiety and depression Confusion Muscle pains Mouth sores Low energy or fatigue Worsening of PMS symptoms Worsening symptoms of anemia Because vitamin B6 is incredibly important for nerve function, a vitamin B6 deficiency is sometimes associated with neuropsychiatric disorders, including seizures, migraines, chronic pain and mood disorders, like depression