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The mechanism of induction of phase II enzyme expression by plant polyphenols has been elucidated by Zoete and colleagues [233]

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It is hypothesized that in patients with PD, because of an increased proinflammatory state, the blood-brain barrier is even more permeable and as MRI studies show, iron accumulation targets neurons and glia of SN, putamen and globus pallidus (Ward et al., 2014)