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As a result of its circumferential wrapping, the outer, uncompacted edge of the glial cell exhibits a series of loops invaginating the axon ( Salzer and Zalc, 2016)

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While selenium deficiency is a major etiological factor of Keshan disease (54), the seasonal and annual variation in disease occurrence suggested that other factors, especially an infectious agent, might be involved in addition to selenium deficiency (55)