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Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice

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Murine T eff cells depend on aerobic glycolysis to enable the rapid growth and proliferation essential for clonal expansion, migration and effector functions ( reg cells have less of the glucose transporter GLUT1 on the surface and rely on lipid oxidation and OXPHOS to generate ATP ( + memory T cells primarily rely on lipid oxidation, the TCA cycle and OXPHOS, utilizing extracellular glucose to synthesize lipids rather than using extracellular fatty acids directly (78, 79) whereas activated effector CD8 + T cells shift their metabolism toward glycolysis