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Baricitinib (JAK1/TYK2 inhibitor, NCT02759731) and pacritinib (JAK2 inhibitor, NCT05531786), if successful in their phase 1/2 trials, could join ruxolitinib in the treatment of cGHVD
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We assume that both treatments, notably the niosomal forms, significantly succeeded in protecting against ATZ-induced steroidogenic machinery disruption through overexpression of 3β-HSD , STAR , and CYP11A1 in the testes
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