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Keywords: human red blood cells, senescence, oxidative stress, hemoglobin, volume, vesicles, naturally occurring antibodies Red blood cell ageing parameters and the criteria of evaluation Over the years many investigators of red blood cells (RBC) and their biochemical properties have centrifuged whole blood and used the RBC pellet without actively removing leucocytes/platelets, despite their simple and selective depletion has been introduced and recommended almost 40 years ago by Beutler et al

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But with species-specific, tissue-specific, and dose-dependent roles in seemingly contradictory physiological processes, a complete understanding of FGF21 physiology is still elusive (233)