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Since C-terminal residues are known to be involved in the trafficking to lysosome, inclusion of additional residues downstream to the C-terminus was probably affecting its localization

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The 2023 international guideline supports metformin for adults with PCOS and BMI ≥ 25 kg/m² for metabolic outcomes, but inositol is a reasonable alternative or adjunct for women who don't tolerate metformin or prefer a non-pharmaceutical option