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They tested these inhibitors in cell and animal models.² They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions.² These outcomes have increased scientific interest in NNMT biology
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Interestingly, a recent study in Danish population showed that lower serum vitamin B12 concentrations were significantly associated higher BMI, but a genetic risk score related to vitamin B12 concentrations associated variants was not associated with BMI
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