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We also found no involvement of FGF-2 in Lu99 cell proliferation in vitro, but further studies are needed to confirm whether FGF-2 inhibition by its neutralising antibodies and multi-tyrosine kinase inhibitors targeting FGF receptors suppresses tumour growth of NSCLC cells including A549 cells, in which serum-free culture could not be adapted and FGF-2 expression was extremely lower than in Lu99 cells, through in vivo assays to test the anti-angiogenic effect
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At the 3-month follow-up, 100% of participants in the treatment group exhibited a reduction of at least 20% in their Hamilton Depression Rating Scale (HAM-D) scores, compared to 69% in the control group
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