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Ralph Carmel, uno de los principales investigadores de la vitamina B12, publica un estudio en 1988 con varios sujetos analizados donde se sugiere la relación de que a más cantidad de análogos acumulados mayor riesgo de sintomatología neurológica y que ello podría explicar porqué algunos pacientes no experimentaban síntomas neurológicos (al menos hasta el momento) pero sí anemias

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However, cyanocobalamin works well for most people and costs significantly less