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133 Talin has been implicated in controlling integrin α IIb β 3 activation, by binding to the cytoplasmic domain of integrin β 3 when phosphorylated and/or cleaved by calpain (see “Integrin αIIbβ3” below and Fig

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A series of recent publications has demonstrated that, in proliferating cells, the pentose phosphate pathway and the previously underestimated THF metabolism have nearly comparable contributions to the regeneration of NADPH from NADP + 54,55,56,57 (Fig