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In addition, further consideration might be given to the counteraction of increased liver values of interleukin-6, tumor necrosis factor alpha and interleukin-1β[25], and the relation with counteracted tumor cachexia[18], muscle wasting, increased pro-cachectic and pro-inflammatory mediators, and changes in the expression of forkhead box O3, phosphorylated protein kinase B, phosphorylated mammalian target of rapamycin, and phosphorylated glycogen synthase kinase 3β[18]