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Reported response rates to this protocol are excellent, with 59% to 76% of cats achieving complete clinical remission, reported median survival times ranging from 20 to 30 months for those cats responding to therapy, and reports of individual cats surviving as long as 76 months.43, 73, 84 The original reported protocol comprised prednisolone (10 mg/cat, PO or 2 mg/kg, PO) given daily with chlorambucil pulsed by administration of 15 mg/m 2 for 4 days every 3 weeks