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Age-associated chronic inflammation was found to be mediated by IL-11 through activating the ERK-adenosine monophosphate-activated protein kinase (AMPK)-mechanistic target of rapamycin complex 1 (mTORC1) axis, and Janus kinase (JAK)-signal transducer and activator of transcription (JAK-STAT) signaling pathway

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Then, more measurable weight loss occurs in the first 2 to 3 months, and increases over 6 to 12 months (SURMOUNT-1)